Product description:

Phenylalanine has metabolic roles in mood elevation and appetite suppression. Also being trialed in the treatment of sickle cell anaemia.

What does L-Phenylalanine do?

The alpha-amino acid Phenylalanine exists in two forms, the D- and L- forms, which are enantiomers (mirror-image molecules) of each other. It has a benzyl side chain. Its name comes from its chemical structure's consisting of a phenyl group substituted for one of the hydrogens in the side chain of alanine. Because of its phenyl group, phenylalanine is an aromatic compound. At room temperature, it is a white, powdery solid.

L-Phenylalanine (LPA) is an electrically-neutral amino acid, one of the twenty common amino acids used to biochemically form proteins, coded for by DNA. Its enantiomer, D-phenylalanine (DPA), can be synthesized artificially.

L-phenylalanine is used in living organisms, including the human body, where it is an essential amino acid. L-phenylalanine can also be converted into L-tyrosine, another one of the twenty protein-forming amino acids. L-tyrosine is converted into L-DOPA, which is further converted into dopamine, norepinephrine, and epinephrine (latter three are known as the catecholamines). D-phenylalanine can be converted only into phenylethylamine.

The genetic disorder phenylketonuria is an inability to metabolize phenylalanine. Individuals with this disorder are known as "phenylketonurics", and must abstain from consumption of phenylalanine. It is present in many sugarless gums and other food products, which are labeled: "Phenylketonurics: Contains phenylalanine." The reason is not that phenylalanine is in the food per se. Aspartame (Nutrasweet) is an ester that is hydrolyzed in the body to form methanol and phenylalanine, which then builds up in the person with PKU.

The synthesized mix DL-Phenylalanine (DLPA), which is a combination of the D- and L- forms (e.g. a racemate), is used as a nutritional supplement.

The genetic codon for phenylalanine was the first to be discovered. Marshall W. Nirenberg discovered that, when he inserted m-RNA made up of multiple uracil repeats into E. coli, the bacterium produced a new protein, made up solely of repeated phenylalanine amino acids.

Phenylalanine uses the same active transport channel as tryptophan to cross the blood-brain barrier, and, in large quantities, interferes with the production of serotonin.

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